Article
The FimH A27V mutation is pathoadaptive for urovirulence in Escherichia coli B2 phylogenetic group isolates.
Infection and immunity - 1 Jun 2003
Hommais Florence, Gouriou Stéphanie, Amorin Christine, Bui Hung, Rahimy Mohamed Chérif, Picard Bertrand, Denamur Erick
Abstract excerpt
Correlations between FimH mutations and virulence were established by studying a collection of human commensal and extraintestinal pathogenic Escherichia coli natural isolates. Pathoadaptive (A27V and, to a lesser extent, A119V) and "commensal-adaptive" (A202V) mutations were evidenced in B2 phylogenetic group strains. fimH phylogenetic analysis indicates that these pathoadaptive mutations occurred several times.
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