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Article

The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism.

Metabolism: clinical and experimental - 1 May 2003

Pihlajamäki Jussi, Karhapää Pauli, Vauhkonen Ilkka, Kekäläinen Päivi, Kareinen Anu, Viitanen Laura, Pesonen Ullamari, Kallio Jaana, Uusitupa Matti, Laakso Markku

Abstract excerpt

The Leu7Pro polymorphism in the signal peptide of the preproneuropeptide Y (NPY) has been associated with dyslipidemias and free fatty acid (FFA) levels during exercise. The association of this polymorphism with insulin sensitivity has not been studied. In this study, the Leu7Pro polymorphism was determined in 2 groups of nondiabetic middle-aged subjects (n = 266 and n = 295). Insulin sensitivity was measured...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12759898
DOI: 10.1053/meta.2003.50098

Genes

NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The Leu7Pro polymorphism of the neuropeptide Y gene regulates free fatty acid metabolism.PMID 12759898Read ↗

The impact of the leucine 7 to proline 7 polymorphism of the neuropeptide Y gene on postprandial lipemia and on the response of serum total and lipoprotein lipids to a reduced fat diet.Semantic proximity Read ↗

Changes in diurnal sympathoadrenal balance and pituitary hormone secretion in subjects with Leu7Pro polymorphism in the prepro-neuropeptide Y.Semantic proximity Read ↗

Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels.Semantic proximity Read ↗

The Leu7Pro polymorphism of preproNPY is associated with decreased insulin secretion, delayed ghrelin suppression, and increased cardiovascular responsiveness to norepinephrine during oral glucose tolerance test.Semantic proximity Read ↗

Association of Neuropeptide Y Gene rs16147 Polymorphism with Cardiovascular Risk Factors, Adipokines, and Metabolic Syndrome in Patients with Obesity.Semantic proximity Read ↗

Neuropeptide Y Leu7Pro polymorphism associated with the metabolic syndrome and its features in patients with coronary artery disease.Semantic proximity Read ↗

Nutrient intake, weight, and Leu7Pro polymorphism in prepro-neuropeptide Y in children.Semantic proximity Read ↗

Variation in the 5'-flanking region of the neuropeptide Y2 receptor gene and metabolic parameters.Semantic proximity Read ↗

Polymorphism of neuropeptide Y gene rs16147 modifies the response to a hypocaloric diet on cardiovascular risk biomarkers and adipokines.Semantic proximity Read ↗

Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects.Semantic proximity Read ↗

Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men.Semantic proximity Read ↗

Neuropeptide Y polymorphism significantly magnifies diabetes and cardiovascular disease risk in obesity: the Hoorn Study.Semantic proximity Read ↗

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