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Article

Cellular cardiomyoplasty—cardiomyocytes, skeletal myoblasts, or stem cells for regenerating myocardium and treatment of heart failure?

1 May 2003

Abstract excerpt

Time for primary review 23 days. In newts, excision of up to 50% of the ventricular myocardium results in spontaneous regeneration and rebuilding of the heart, a process that involves de-differentiation of the remaining cardiomyocytes, de-novo synthesis of DNA followed by proliferation and mitotic cell division of both cardiomyocytes and connective tissue, and subsequent replacing of the lost tissue [1–3]. In...

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PMID: 12757870
DOI: 10.1016/s0008-6363(02)00739-3

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