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Article

Modeling bacterial evolution with comparative-genome-based marker systems: application to Mycobacterium tuberculosis evolution and pathogenesis.

Journal of bacteriology - 1 Jun 2003

Alland David, Whittam Thomas S, Murray Megan B, Cave M Donald, Hazbon Manzour H, Dix Kim, Kokoris Mark, Duesterhoeft Andreas, Eisen Jonathan A, Fraser Claire M, Fleischmann Robert D

Abstract excerpt

The comparative-genomic sequencing of two Mycobacterium tuberculosis strains enabled us to identify single nucleotide polymorphism (SNP) markers for studies of evolution, pathogenesis, and epidemiology in clinical M. tuberculosis. Phylogenetic analysis using these "comparative-genome markers" (CG...

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Identifiers

PMID: 12754238
DOI: 10.1128/JB.185.11.3392-3399.2003
PMCID: PMC155390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12754238-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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