Article
Substrate specificity of type III flagellar protein export in Salmonella is controlled by subdomain interactions in FlhB.
Molecular microbiology - 1 May 2003
Fraser Gillian M, Hirano Takanori, Ferris Hedda U, Devgan Lara L, Kihara May, Macnab Robert M
Abstract excerpt
FlhB, an integral membrane protein, gates the type III flagellar export pathway of Salmonella. It permits export of rod/hook-type proteins before hook completion, whereupon it switches specificity to recognize filament-type proteins. The cytoplasmic C-terminal domain of FlhB (FlhBC) is cleaved between Asn-269 and Pro-270, defining two subdomains: FlhBCN and FlhBCC. Here, we show that subdomain interactions and...
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