Article
Susceptibility to highly sulphated glycosaminoglycans of human immunodeficiency virus type 1 replication in peripheral blood lymphocytes and monocyte-derived macrophages cell cultures.
Antiviral research - 1 Apr 2003
Bartolini Barbara, Di Caro Antonino, Cavallaro Rosaria A, Liverani Lino, Mascellani Giuseppe, La Rosa Giuseppina, Marianelli Cinzia, Muscillo Michele, Benedetto Arrigo, Cellai Luciano
Abstract excerpt
In the search for new drugs against human immunodeficiency virus type 1 (HIV-1), the replication of III(B) and BaL strains, and of seven primary isolates from AIDS patients, cultured both in peripheral blood lymphocytes (PBLs) and in monocyte-derived macrophages (MACs), was investigated in the presence of two dermatan sulphate and heparin at 10 microg/ml. The three polysaccharides effectively inhibited the...
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