Article
The use of androgen receptor amino/carboxyl-terminal interaction assays to investigate androgen receptor gene mutations in subjects with varying degrees of androgen insensitivity.
The Journal of clinical endocrinology and metabolism - 1 May 2003
Ghali Shereen A, Gottlieb Bruce, Lumbroso Rose, Beitel Lenore K, Elhaji Youssef, Wu Jian, Pinsky Leonard, Trifiro Mark A
Abstract excerpt
Five mutations in the ligand-binding domain (LBD) of the human androgen receptor (hAR) found in patients with varying degrees of androgen insensitivity syndrome (AIS) were investigated for their effects on receptor dynamics. These were Arg(871)Gly (mild), Ser(814)Asn (partial), Glu(772)Ala (partial), Val(866)Met (complete), and Arg(774)Cys (complete). Previous analysis showed that the mutant receptors exhibited...
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