Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol.

The Journal of biological chemistry - 18 Jul 2003

Sugii Shigeki, Reid Patrick C, Ohgami Nobutaka, Du Hong, Chang Ta-Yuan

Abstract excerpt

We previously studied the early trafficking of low density lipoprotein (LDL)-derived cholesterol in mutant Chinese hamster ovary cells defective in Niemann-Pick type C1 (NPC1) using cyclodextrin (CD) to monitor the arrival of cholesterol from the cell interior to the plasma membrane (PM) (Cruz, J. C., Sugii, S., Yu, C., and Chang, T.-Y. (2000) J. Biol. Chem. 275, 4013-4021). We found that newly hydrolyzed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein A-I
Share to Biological Transport, Active

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Compartmentation

Share to Endosomes

Share to Lipoproteins, HDL

Share to Membrane Lipids

Share to Niemann-Pick C1 Protein

Share to Niemann-Pick Diseases

Source

Identifiers

PMID: 12721287
DOI: 10.1074/jbc.M300542200

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol.PMID 12721287Read ↗

Trafficking defects in endogenously synthesized cholesterol in fibroblasts, macrophages, hepatocytes, and glial cells from Niemann-Pick type C1 mice.Semantic proximity Read ↗

Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol.Semantic proximity Read ↗

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.Semantic proximity Read ↗

Function of the Niemann-Pick type C proteins and their bypass by cyclodextrin.Semantic proximity Read ↗

Impaired dynamics of the late endosome/lysosome compartment in human Niemann-Pick type C skin fibroblasts carrying mutation in NPC1 gene.Semantic proximity Read ↗

Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols.Semantic proximity Read ↗

Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System.Semantic proximity Read ↗

Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events.Semantic proximity Read ↗

Intracellular trafficking of the free cholesterol derived from LDL cholesteryl ester is defective in vivo in Niemann-Pick C disease: insights on normal metabolism of HDL and LDL gained from the NP-C mutation.Semantic proximity Read ↗

Niemann-Pick type C1 protein influences the delivery of cholesterol to the SREBP:SCAP complex.Semantic proximity Read ↗

Cyclodextrin Induces Calcium-Dependent Lysosomal ExocytosisSemantic proximity Read ↗

Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.