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Article

Inhibition of Transcription Factor Stat5 Induces Cell Death of Human Prostate Cancer Cells

1 Jul 2003

Abstract excerpt

Identifying regulators of prostate cancer cell survival may lead to new therapeutic strategies for prostate cancer. We now report prevalent activation of transcription factor Stat5 in human prostate cancer and provide novel evidence that blocking activation of Stat5 in human prostate cancer cells leads to extensive cell death. Specifically, Stat5 was activated in 65% of human prostate cancer specimens examined...

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PMID: 12719422
DOI: 10.1074/jbc.m304307200

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Transcription Factor Stat5 Induces Cell Death of Human Prostate Cancer CellsPMID 12719422Read ↗

Transcription Factor Stat5 Synergizes with Androgen Receptor in Prostate Cancer CellsSemantic proximity Read ↗

Transcription Factor Stat3 Stimulates Metastatic Behavior of Human Prostate Cancer Cells in Vivo, whereas Stat5b Has a Preferential Role in the Promotion of Prostate Cancer Cell Viability and Tumor GrowthSemantic proximity Read ↗

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STAT5A/B Gene Locus Undergoes Amplification during Human Prostate Cancer ProgressionSemantic proximity Read ↗

Inhibition of STAT3 signaling targets both tumor-initiating and differentiated cell populations in prostate cancerSemantic proximity Read ↗

Cyclin-dependent kinase 5 acts as a critical determinant of AKT-dependent proliferation and regulates differential gene expression by the androgen receptor in prostate cancer cellsSemantic proximity Read ↗

Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer.Semantic proximity Read ↗

Loss of Stat5a delays mammary cancer progression in a mouse model.Semantic proximity Read ↗

STAT5A/B Blockade Sensitizes Prostate Cancer to Radiation through Inhibition of RAD51 and DNA RepairSemantic proximity Read ↗

Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser⁷²⁷ on STAT3 in prostate cancer cells.Semantic proximity Read ↗

Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor <i>In vivo</i>Semantic proximity Read ↗

Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells.Semantic proximity Read ↗

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