Article
Activating mutation (V617F) in the tyrosine kinase JAK2 is absent in locally-confined or castration-resistant prostate cancer.
Analytical cellular pathology (Amsterdam) - 1 Jan 2010
Gu Lei, Zhu Xian-Hua, Visakorpi Tapio, Alanen Kalle, Mirtti Tuomas, Edmonston Tina Bocker, Nevalainen Marja T
Abstract excerpt
BACKGROUND: Transcription factor Stat5a/b is highly critical for the viability of human prostate cancer cells in vitro and for prostate tumor growth in vivo. Stat5 is constitutively active in clinical prostate cancers but not in the normal human prostate epithelium. Moreover, Stat5a/b activation in prostate cancer is associated with high histological grade of prostate cancer. However, the molecular mechanisms...
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