Article
Wolfram syndrome and suicide: Evidence for a role of WFS1 in suicidal and impulsive behavior.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2003
Sequeira Adolfo, Kim Caroline, Seguin Monique, Lesage Alain, Chawky Nadia, Desautels Alex, Tousignant Michel, Vanier Claude, Lipp Olivier, Benkelfat Chawki, Rouleau Guy, Turecki Gustavo
Abstract excerpt
There is evidence suggesting that subjects affected with the Wolfram syndrome (WFS) and normal carriers present an increased risk of psychiatric disorders, particularly depression and suicidal behavior. We investigated a possible role of the gene involved in WFS (WFS1) in the neurobiology of suicide and the potential modulatory effect on traits associated to suicidal behavior. Genetic variation at WFS1 (H611R,...
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