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Article

Combined protein C and protein S deficiency in a family with repetitive thromboembolism and segregated gene mutations.

Internal medicine (Tokyo, Japan) - 1 Mar 2003

Hayashida Mie, Yamada Hiroyoshi, Yamazaki Satoshi, Nomura Hiroshi, Yoshimura Kazuhiko, Kitahara Osamu, Momose Kunio, Kubo Keishi, Kurihara Masako, Hamasaki Naotaka

Abstract excerpt

A young man with repetitive deep venous thrombosis of the legs and the inferior vena cava, and his family were eventually diagnosed by means of molecular genetic analysis as having both hereditary protein C and protein S deficiency. There have been a few reports of families with combined protein C and protein S deficiency and only one report of such a family characterized at the DNA level. This was the first...

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Identifiers

PMID: 12705793
DOI: 10.2169/internalmedicine.42.268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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