Co-segregation of the PROS1 locus and protein S deficiency in families having no detectable mutations in PROS1.

Abstract excerpt

Inherited deficiency of protein S constitutes an important risk factor of venous thrombosis. Many reports have demonstrated that causative mutations in the protein S gene are found only in approximately 50% of the cases with protein S deficiency. It is uncertain whether the protein S gene is causative in all cases of protein S deficiency or if other genes are involved in cases where no mutation is identified. The...

Topics

• DNA Mutational Analysis
• Family Health
• Female
• Haplotypes
• Humans
• Inheritance Patterns
• Lod Score
• Male
• Microsatellite Repeats
• Mutation
• Pedigree
• Protein S
• Protein S Deficiency