Article
KCNQ1 mutations in patients with a family history of lethal cardiac arrhythmias and sudden death.
Clinical genetics - 1 Apr 2003
Chen S, Zhang L, Bryant R M, Vincent G M, Flippin M, Lee J C, Brown E, Zimmerman F, Rozich R, Szafranski P, Oberti C, Sterba R, Marangi D, Tchou P J, Chung M K, Wang Q
Abstract excerpt
Long QT syndrome (LQTS) is the prototype of the cardiac ion channelopathies which cause syncope and sudden death. LQT1, due to mutations of KCNQ1 (KVLQT1), is the most common form. This study describes the genotype-phenotype characteristics in 10 families with mutations of KCNQ1, including 5 novel mutations. One hundred and two families with a history of lethal cardiac events, 55 LQTS, 9 Brugada syndrome, 18...
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