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Article

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia.

Journal of lipid research - 1 Jun 2003

Hovingh G Kees, Van Wijland Michel J A, Brownlie Alison, Bisoendial Radjesh J, Hayden Michael R, Kastelein John J P, Groen Albert K

Abstract excerpt

Defects in the gene encoding for the ATP binding cassette (ABC) transporter A1 (ABCA1) were shown to be one of the genetic causes for familial hypoalphalipoproteinemia (FHA). We investigated the role of ABCA1-mediated cholesterol efflux in Dutch subjects suffering from FHA. Eighty-eight subjects (mean HDL cholesterol levels 0.63 +/- 0.21 mmol/l) were enrolled. Fibroblasts were cultured and loaded with...

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Source

Identifiers

PMID: 12700344
DOI: 10.1194/jlr.M300080-JLR200

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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