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Article

EGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.

The Journal of clinical investigation - 1 Apr 2003

Teramoto Tetsuyuki, Qiu Jianhua, Plumier Jean-Christophe, Moskowitz Michael A

Abstract excerpt

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion...

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Source

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Identifiers

PMID: 12697732
DOI: 10.1172/JCI17170
PMCID: PMC152938

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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