Article
Experimental evolution and the Krogh principle: generating biological novelty for functional and genetic analyses.
Physiological and biochemical zoology : PBZ - 1 Jan 2000
Bennett Albert F
Abstract excerpt
August Krogh counseled the careful selection of the best subject organism on which to undertake mechanistic physiological research. But what if an organism with the desired properties does not exist? It is now within our power to engineer organisms genetically to achieve novel combinations of traits. I propose that it is a logical extension of the Krogh principle that we use biological methodologies to create...
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