Evolvability of physiological and biochemical traits: evolutionary mechanisms including and beyond single-nucleotide mutation.

Abstract excerpt

A longstanding challenge for biologists has been to explain not just how organisms are adapted to diverse environments, but how these adaptations arise. Although natural selection is clearly sufficient to act on heritable variation, is this heritable variation sufficient to yield complex adaptations and how does this variation itself arise? Much prior focus has been on mutation of single nucleotides in genes....

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