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Article

The natural history of sclerosteosis

1 Mar 2003

Abstract excerpt

Sclerosteosis (SCL) is a severe, progressive, autosomal-recessive craniotubular hyperostosis (MIM 269500). The determinant gene (SOST) has been isolated, and genotype-phenotype correlations, as well as the elucidation of pathogenetic mechanisms, are dependent upon the documentation of the natural history of the condition. For this reason, the course and complications in 63 affected individuals in South Africa,...

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PMID: 12694228
DOI: 10.1034/j.1399-0004.2003.00036.x

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