Article
Alpha-thalassemia mutations in Gilan Province, North Iran.
Hemoglobin - 1 Jan 2009
Hadavi Valeh, Jafroodi Maryam, Hafezi-Nejad Nima, Moghadam Sousan Dehnadi, Eskandari Fatemeh, Tarashohi Shahin, Pourfahim Hamideh, Oberkanins Christian, Law Hai-Yang, Najmabadi Hossein
Abstract excerpt
One hundred and three patients from Gilan Province, Iran, presenting with hypochromic and microcytic anemia parameters without iron deficiency were included in this study. Using gap-polymerase chain reaction (gap-PCR), reverse hybridization StripAssay and DNA sequencing, we detected a total of 113 alpha-globin mutations in 94 (91.3%) of these patients. Most prevalent of the 16 different alpha-thalassemia...
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