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Article

Zinc in the spinal cord of a mutant SOD1 mouse model of ALS.

Neuroreport - 24 Mar 2003

Pamphlett Roger, Kum-Jew Stephen

Abstract excerpt

Both decreases and increases in zinc have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). We therefore examined the distribution of zinc in transgenic mutant superoxide dismutase 1 (SOD1) mice, a model for ALS. Frozen sections of spinal cord from these mice were stained for free zinc with autometallography. Zinc granules in the spinal anterior horn surrounded motor neuron cell bodies...

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Source

Identifiers

PMID: 12657882
DOI: 10.1097/00001756-200303240-00003

Genes

SOD1

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