Article
Cross-sectional analysis of hearing threshold in relation to age in a large family with cochleovestibular impairment thoroughly genotyped for DFNA9/COCH.
The Annals of otology, rhinology, and laryngology - 1 Mar 2003
Bom Steven J H, Kemperman Martijn H, Huygen Patrick L M, Luijendijk Mirjam W J, Cremers Cor W R J
Abstract excerpt
Hearing threshold was analyzed for each frequency in relation to age in 88 members of a large Dutch family with cochleovestibular impairment caused by a P51S mutation in the COCH gene within the DFNA9 locus (chromosome 14q12-13). The participants in this study were 34 mutation carriers and 54 relatives without the mutation (control subjects). A sigmoidal dose-response curve with a variable slope was used to fit...
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