Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

APOE genotype is a risk factor for neuropathy severity in diabetic patients.

Neurology - 25 Mar 2003

Bedlack R S, Edelman D, Gibbs J W, Kelling D, Strittmatter W, Saunders A M, Morgenlander J

Abstract excerpt

This cross-sectional study tested the hypothesis that APOE genotype is a risk factor for diabetic neuropathy severity. A model with age, duration of diabetes, and APOE genotype was found to predict (p = 0.0083) severity on the Neuropathy Impairment Score in the Lower Limbs (NISLL). Considering genotype alone, patients with APOE 3/4 and 4/4 genotypes had 3 more NISLL points than patients with other genotypes. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Severity of Illness Index
Share to Aged
Share to Apolipoproteins E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies

Share to Diabetes Mellitus, Type 2

Share to Diabetic Neuropathies

Share to Genetic Predisposition to Disease

Share to Risk Factors

Source

Identifiers

PMID: 12654974
DOI: 10.1212/01.wnl.0000056689.50682.94

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

APOE genotype is a risk factor for neuropathy severity in diabetic patients.PMID 12654974Read ↗

The ε4 allele of the APOE gene is associated with more severe peripheral neuropathy in type 2 diabetic patients.Semantic proximity Read ↗

State of the art paper APOE gene polymorphisms and diabetic peripheral neuropathySemantic proximity Read ↗

Genetic Variants Influence the Development of Diabetic Neuropathy.Semantic proximity Read ↗

Recent advances in exploring the genetic susceptibility to diabetic neuropathy.Semantic proximity Read ↗

[Risk factors and onset mechanisms of diabetic neuropathy].Semantic proximity Read ↗

Effects of Common Polymorphisms in the MTHFR and ACE Genes on Diabetic Peripheral Neuropathy Progression: a Meta-Analysis.Semantic proximity Read ↗

[The examination of apoE phenotypes in diabetic patients with peripheral neuropathy].Semantic proximity Read ↗

Mediators of diabetic neuropathy: is hyperglycemia the only culprit?Semantic proximity Read ↗

Angiotensin-converting enzyme gene single polymorphism as a genetic biomarker of diabetic peripheral neuropathy: longitudinal prospective study.Semantic proximity Read ↗

Relationship Between the ApoE Gene Polymorphism and Type 2 Diabetes Mellitus Complications.Semantic proximity Read ↗

Prevalence of Peripheral Neuropathy and Association Between Cardiovascular Disease and Adult Non-Diabetic Peripheral Neuropathy in TrinidadSemantic proximity Read ↗

Association between a MIR499A polymorphism and diabetic neuropathy in type 2 diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.