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In vivo measurement of brain metabolites using two‐dimensional double‐quantum MR spectroscopy—exploration of GABA levels in a ketogenic diet

18 Mar 2003

Abstract excerpt

A localized proton 2D double-quantum (DQ) spin-echo spectroscopy technique was implemented on 1.5 T clinical MRI scanners for the detection of gamma-aminobutyrate (GABA) in the brain. The 2D approach facilitates separation of peaks overlapping with GABA in 1D DQ-filtered (DQF) spectra. This technique was applied to four normal adult volunteers and four children with intractable epilepsy. The coefficient of...

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PMID: 12652530
DOI: 10.1002/mrm.10429

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