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Article

Immunohistochemical study on the distribution of homocysteine in the central nervous system of transgenic mice expressing a human Cu/Zn SOD mutation.

Brain research - 28 Mar 2003

Chung Yoon Hee, Hong Jin-Joo, Shin Chung Min, Joo Kyeung Min, Kim Myeung Ju, Cha Choong Ik

Abstract excerpt

In the present study, we used the transgenic mice expressing a human Cu/Zn SOD mutation (SOD1(G93A)) as an in vivo model of ALS and performed immunohistochemical studies to investigate the changes of homocysteine in the central nervous system of symptomatic transgenic mice. In control and presymptomatic transgenic mice, homocysteine-immunoreactive astrocytes were not detected in any region. In symptomatic...

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Identifiers

PMID: 12650983
DOI: 10.1016/s0006-8993(03)02238-8

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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