Article
A twisted tRNA intermediate sets the threshold for decoding.
RNA (New York, N.Y.) - 1 Apr 2003
Yarus Michael, Valle Mikel, Frank Joachim
Abstract excerpt
Putting together consistent cryo-EM structure, transient kinetic and mutant tRNA suppressor data, it appears that a deformed or waggling aminoacyl-tRNA is the critical transitional structure examined by the ribosome during decoding at the A site. The unusual conformation may be required for effective proofreading of the codon-anticodon complex.
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