Article
The apolipoprotein epsilon4 allele confers additional risk in children with familial hypercholesterolemia.
Pediatric research - 1 Jun 2003
Wiegman Albert, Sijbrands Eric J G, Rodenburg Jessica, Defesche Joep C, de Jongh Saskia, Bakker Henk D, Kastelein John J P
Abstract excerpt
Children with familial hypercholesterolemia (FH) exhibit substantial variance of LDL cholesterol. In previous studies, family members of children with FH were included, which may have influenced results. To avoid such bias, we studied phenotype in 450 unrelated children with FH and in 154 affected sib-pairs. In known families with classical FH, diagnosis was based on plasma LDL cholesterol above the age- and...
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