Article
Genetic dissection between silent and clinically diagnosed symptomatic forms of coeliac disease in multiplex families.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Dec 2002
Mustalahti K, Holopainen P, Karell K, Mäki M, Partanen J
Abstract excerpt
BACKGROUND: Coeliac disease has a large variation in clinical outcome. In addition to the classical disease with malabsorption, many individuals have a silent form, in which subject symptoms are missing but autoantibodies and mucosa lesions are identical to the symptomatic disease. AIM: To investigate whether differences in HLA DR-DQ genes explain the variation in outcome. MATERIALS AND METHODS: HLA DQ alleles...
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