Article
[Genetic analysis of spontaneous suppressors of the pho85 mutation in the yeast Saccharomyces cerevisiae].
Genetika - 1 Jan 2003
Sambuk E V, Popova Iu G, Padkina M V
Abstract excerpt
Chaperones are known to play an important role in complexation of cyclin-dependent kinases with cyclins. In yeast cells growing in the presence of phosphate, cyclin-dependent kinase Pho85p and cyclin Pho80p form a complex and phosphorylate activator Pho4p. As a result, Pho4p is exported from the nucleus, and the PHO5 gene is not transcribed. The mutations suppressing the pho85 mutation were analyzed in order to...
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