Article
Medulloblastoma With Adverse Reaction to Radiation Therapy in Nijmegen Breakage Syndrome
1 Mar 2003
Abstract excerpt
A 3-year-old child with microcephaly, facial dysmorphism, growth retardation, and developmental delay was diagnosed with medulloblastoma. Craniospinal irradiation resulted in severe radiation-induced dermatitis and gastroesophagitis, unresponsive to further medical therapy. Colony survival assay on the patient's transformed lymphocytes revealed a high degree of radiosensitivity ex vivo. The presence of radiation...
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