Article
Cefuroxime resistance in non-beta-lactamase Haemophilus influenzae is linked to mutations in ftsI.
The Journal of antimicrobial chemotherapy - 1 Mar 2003
Straker K, Wootton M, Simm A M, Bennett P M, MacGowan A P, Walsh T R
Abstract excerpt
The penicillin binding protein (PBP) genes dacA, dacB and ftsI from 14 cefuroxime-resistant (CXM(R)) isolates and three clinical isolates with low CXM MIC for non-beta-lactamase-producing Haemophilus influenzae type b were molecularly characterized. One strain, 5788, was used to transform H. influenzae Rd to CXM(R) for direct comparison of the pbps in the same genetic background. No obvious mutations in the dacA...
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