Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.

doi:10.1038/ng1089

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Article

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.

Nature genetics - 1 Mar 2003

Jaenisch Rudolf, Bird Adrian

Abstract excerpt

Cells of a multicellular organism are genetically homogeneous but structurally and functionally heterogeneous owing to the differential expression of genes. Many of these differences in gene expression arise during development and are subsequently retained through mitosis. Stable alterations of t...

Topics

Aging
Animals
Cloning, Organism
DNA Methylation
Diet
Dosage Compensation, Genetic
Gene Expression Regulation, Developmental
Genetic Diseases, Inborn
Genome
Genomic Imprinting
Humans
Mice
Models, Genetic
Mutation
Neoplasms
Phenotype
Signal Transduction

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