Article
Lack of association in Japanese patients between neuroleptic malignant syndrome and the TaqI A polymorphism of the dopamine D2 receptor gene.
Psychiatric genetics - 1 Mar 2003
Kishida Ikuko, Kawanishi Chiaki, Furuno Taku, Matsumura Takehiko, Hasegawa Hana, Sugiyama Naoya, Suzuki Kyoko, Yamada Yoshiteru, Kosaka Kenji
Abstract excerpt
OBJECTIVE: The molecular basis of neuroleptic malignant syndrome (NMS) is unclear, but clinical studies have noted a genetic predisposition. A recent genetic study suggested an association between NMS and the I A polymorphism in the dopamine D2 receptor (DRD2 ) gene. We further examined the association in a larger number of subjects. METHODS: We studied 49 Japanese patients previously diagnosed with NMS, and 123...
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