Article
Differentially expressed genes associated with CIS-diamminedichloroplatinum (II) resistance in head and neck cancer using differential display and CDNA microarray.
Head & neck - 1 Mar 2003
Higuchi Eisaku, Oridate Nobuhiko, Furuta Yasushi, Suzuki Seigo, Hatakeyama Hiromitsu, Sawa Hirofumi, Sunayashiki-Kusuzaki Kousaku, Yamazaki Ken-Ichi, Inuyama Yukio, Fukuda Satoshi
Abstract excerpt
BACKGROUND: The mechanism by which cancer cells become resistant to cis-Diamminedichloroplatinum (II) (cDDP) is not completely understood. To investigate the molecular markers involved in the cDDP resistance, we compared the gene expression profiles between a head and neck squamous cell carcinoma (HNSCC) line sensitive to cDDP and its cDDP-resistant variant. METHODS: Both a fluorescent differential display and a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.