Article
Sudden infant death syndrome: association with a promoter polymorphism of the serotonin transporter gene.
American journal of medical genetics. Part A - 15 Mar 2003
Weese-Mayer Debra E, Berry-Kravis Elizabeth M, Maher Brion S, Silvestri Jean M, Curran Mark E, Marazita Mary L
Abstract excerpt
Serotonergic receptor binding in the arcuate nucleus, n. raphé obscurus, and other medullary regions is decreased in sudden infant death syndrome (SIDS) cases. Further, a variable tandem repeat sequence polymorphism in the promoter region of the serotonin transporter protein (5-HTT) gene has recently been associated with risk of SIDS in a Japanese cohort. This polymorphism differentially regulates 5-HTT...
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