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Article

Sudden infant death syndrome revisited: serotonin transporter gene, polymorphisms and promoter methylation.

Pediatric research - 1 Sept 2022

Pfisterer Nina, Meyer-Bockenkamp Fiona, Qu Dong, Preuss Vanessa, Rothämel Thomas, Geisenberger Dorothee, Läer Katharina, Vennemann Benedikt, Albers Anne, Engelmann Theresa A, Frieling Helge, Rhein Mathias, Klintschar Michael

Abstract excerpt

BACKGROUND: Based on findings in the brain stems of SIDS victims, the serotonin transporter (5-HTT) gene has been discussed to be associated with SIDS. METHODS: In the largest study to date, we investigated the promoter length (5-HTTLPR) and intron 2 VNTR polymorphisms in 274 cases and 264 controls and the Ile425Val polymorphism in 65 cases and 64 controls. Moreover, the methylation of the internal promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34764460
DOI: 10.1038/s41390-021-01773-3
PMCID: PMC9556327

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