Article
The relationship between pituitary tumour transforming gene (PTTG) expression and in vitro hormone and vascular endothelial growth factor (VEGF) secretion from human pituitary adenomas.
European journal of endocrinology - 1 Feb 2003
Hunter J A C, Skelly R H, Aylwin S J B, Geddes J F, Evanson J, Besser G M, Monson J P, Burrin J M
Abstract excerpt
OBJECTIVE: Pituitary tumour transforming gene (PTTG) is a recently identified protooncogene, ubiquitously expressed in pituitary tumours at levels higher than those detected in normal pituitary. Although the precise function of PTTG protein is unknown, in vitro experiments have shown that it induces angiogenesis. In this study, we have examined the potential relationship between the level of PTTG expression and...
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