The pathogenesis of Crohn's disease in the 21st century.

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Article

The pathogenesis of Crohn's disease in the 21st century.

Pathology - 1 Dec 2002

Hume Georgia, Radford-Smith Graham L

Abstract excerpt

Ten years ago Crohn's disease remained a highly complex disorder with an unknown aetiology and a poorly understood pathogenesis. Research in this field had repeatedly confirmed the presence of an activated intestinal immune system but the factors underlying this had not been identified. Since then, the significance of genetic susceptibility has been established and underlined by the discovery of the NOD2 gene. In...

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Share to Immune System
Share to Carrier Proteins
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Share to Digestive System
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Share to Intracellular Signaling Peptides and Proteins
Share to Nod2 Signaling Adaptor Protein
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Source

Open in PubMed

Identifiers

PMID: 12555995

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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