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Article

Frequency of p53 mutations in breast carcinomas from Ashkenazi Jewish carriers of BRCA1 mutations.

Journal of the National Cancer Institute - 3 Mar 1999

Phillips K A, Nichol K, Ozcelik H, Knight J, Done S J, Goodwin P J, Andrulis I L

Abstract excerpt

BACKGROUND: Breast carcinomas occurring in carriers of BRCA1 gene mutations may have a distinctly different pathway of molecular pathogenesis from those occurring in noncarriers. Data from murine models implicate loss of p53 (also known as TP53) gene function as a critical early event in the malignant transformation of cells with a BRCA1 mutation. Therefore, breast tumors from BRCA1 mutation carriers might be...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, p53

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Share to Polymorphism, Single-Stranded Conformational

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 10070948
DOI: 10.1093/jnci/91.5.469

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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