Article
Predominance of pre-S1 mutated hepatitis B virus in a patient following treatment with adefovir dipivoxil.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Feb 2003
Villa Erica, Boarino Valentina, Grottola Antonella, Gelmini Roberta, Lama Nicole G
Abstract excerpt
A liver transplant recipient reinfected with a lamivudine-resistant mixed wild-type/pre-S1-deleted hepatitis B virus (HBV) strain and rescued with adefovir dipivoxil was still HBV DNA positive after more than 1 year of therapy. Analysis of serum HBV DNA, amplified by polymerase chain reaction and directly sequenced by dideoxy nucleotide chain-termination method, showed that adefovir inhibited the wild type, but...
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