Article
BRCA1 and BRCA2 mutation status and tumor characteristics in male breast cancer: a population-based study in Italy.
Cancer research - 15 Jan 2003
Ottini Laura, Masala Giovanna, D'Amico Cristina, Mancini Biancamaria, Saieva Calogero, Aceto Gitana, Gestri Donella, Vezzosi Vania, Falchetti Mario, De Marco Manola, Paglierani Milena, Cama Alessandro, Bianchi Simonetta, Mariani-Costantini Renato, Palli Domenico
Abstract excerpt
To investigate at the population level the impact of BRCA1/BRCA2 gene alterations in male breast cancer, we analyzed a population-based series of 25 male breast cancer cases from Florence, Central Italy. We combined mutational screening with the study of germ-line allele transcript levels and of tumor-associated losses of heterozygosity. Screening by protein truncation test and single-strand conformational...
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