Closing the (Ran)GAP on segregation distortion in Drosophila.

doi:10.1002/bies.10222

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Article

Closing the (Ran)GAP on segregation distortion in Drosophila.

BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 2003

Kusano Ayumi, Staber Cynthia, Chan Ho Yin Edwin, Ganetzky Barry

Abstract excerpt

Segregation Distorter (SD) is a meiotic drive system in Drosophila that causes preferential transmission of the SD chromosome from SD/SD(+) males owing to induced dysfunction of SD(+) spermatids. Since its discovery in 1956, SD and its mode of action have baffled biologists. Recently, substantial progress has been made in elucidating this puzzle. Sd, the primary gene responsible for distortion encodes a mutant...

Topics

Animals
Drosophila Proteins
Drosophila melanogaster
Female
GTPase-Activating Proteins
Genes, Insect
Male
Models, Genetic
Mutation
Spermatozoa

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Open in PubMed

Identifiers

PMID: 12539236
DOI: 10.1002/bies.10222

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