Article
Crystine: fibrous biomolecular material from protein crystals cross-linked in a specific geometry.
Protein engineering - 1 Nov 2002
Srinivasan U, Iyer G H, Przybycien T A, Samsonoff W A, Bell J A
Abstract excerpt
Cysteine substitutions were engineered on the surface of maltose binding protein to produce crystine fibers, linear polymers of folded protein formed within a crystal. Disulfide bond formation between adjacent protein molecules within the lattice was monitored by X-ray crystallography. The cross-linked crystals were resistant to dissolution in water or neutral buffer solutions, even though the cross-linking was...
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