Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Cytogenetic Aberrations in Autosomal Dominant Polycystic Kidney Disease Tissue

1 Feb 2003

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder characterized by focal cyst formation from any part of the nephron. The molecular bases include germinal mutation of either PKD1 or PKD2 genes, enhanced expression of several protooncogenes, alteration of the TGF-alpha/EGF/EGF receptor (EGFR) axis, and disturbed regulation of proliferative/apoptosis pathways. To identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Kidney Cyst Diseases
Share to Renal and related cancers
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12538736
DOI: 10.1097/01.asn.0000046963.60910.63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Cytogenetic Aberrations in Autosomal Dominant Polycystic Kidney Disease TissuePMID 12538736Read ↗

Detection of PKD1 and PKD2 Somatic Variants in Autosomal Dominant Polycystic Kidney Cyst Epithelial Cells by Whole-Genome Sequencing.Semantic proximity Read ↗

A loss-of-function model for cystogenesis in human autosomal dominant polycystic kidney disease type 2.Semantic proximity Read ↗

The Link between Autosomal Dominant Polycystic Kidney Disease and Chromosomal Instability: Exploring the Relationship.Semantic proximity Read ↗

Genome-Scale Single Nucleotide Resolution Analysis of DNA Methylation in Human Autosomal Dominant Polycystic Kidney DiseaseSemantic proximity Read ↗

Germinal and somatic mutations in the PKD2 gene of renal cysts in autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Up-Regulation of DNA Damage Response Signaling in Autosomal Dominant Polycystic Kidney Disease.Semantic proximity Read ↗

The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I.Semantic proximity Read ↗

The polycystic kidney disease 1 gene encodes a 14 kb transcript and lies within a duplicated region on chromosome 16. The European Polycystic Kidney Disease Consortium.Semantic proximity Read ↗

Somatic PKD2 mutations in individual kidney and liver cysts support a "two-hit" model of cystogenesis in type 2 autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Novel Chromosomal Abnormalities Identified by Comparative Genomic Hybridization in Parathyroid Adenomas1Semantic proximity Read ↗

[Heterozygosity loss and somatic mutations in type I and II dominant autosomal renal polycystic kidney disease: evidence of a recessive mechanism at a cell level in cystogenesis].Semantic proximity Read ↗

Loss of heterozygosity in renal and hepatic epithelial cystic cells from ADPKD1 patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.