Article
Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis.
Clinical science (London, England : 1979) - 1 May 2003
Watson Mark A, Gay Laura, Stebbings William S L, Speakman Chris T M, Bingham Sheila A, Loktionov Alexandre
Abstract excerpt
Apolipoprotein E ( ApoE ) gene polymorphism is a major factor in lipid metabolism. It has been suggested that this polymorphism can modulate colorectal tumour risk. We tested this hypothesis for colorectal cancer (CRC). ApoE genotype was determined in 206 patients with CRC and 353 healthy controls from the East Anglia region of the U.K. Compared with individuals possessing the most common epsilon 3/epsilon 3...
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