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Article

Several interacting genes influence the malignant hyperthermia phenotype.

Human genetics - 1 Feb 2003

Robinson Rachel, Hopkins Philip, Carsana Antonella, Gilly Hermann, Halsall Jane, Heytens Luc, Islander Gunilla, Jurkat-Rott Karin, Müller Clemens, Shaw Marie-Anne

Abstract excerpt

Malignant hyperthermia (MH), a potentially lethal disorder of skeletal muscle calcium homeostasis, manifests only on exposure to certain anaesthetic drugs. The mode of inheritance appears to be autosomal dominant with both locus and allelic heterogeneity having been reported. Association analysis of eight MH candidate loci in UK families has indicated that several genes influence susceptibility in individual...

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Identifiers

PMID: 12522565
DOI: 10.1007/s00439-002-0864-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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