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Article

Multiple interacting gene products may influence susceptibility to malignant hyperthermia.

Annals of human genetics - 1 Jul 2000

Robinson R L, Curran J L, Ellis F R, Halsall P J, Hall W J, Hopkins P M, Iles D E, West S P, Shaw M A

Abstract excerpt

Malignant hyperthermia (MH) is a potentially lethal disorder triggered in susceptible individuals on exposure to common anaesthetic agents. Crises reflect the consequences of disturbed skeletal muscle calcium homeostasis. MH is an autosomal dominant, genetically heterogeneous trait. Defects in a single major gene have been assumed to determine susceptibility status in individual families. However, in some...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11415515
DOI: 10.1017/S0003480000008186

Genes

LIPE
RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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