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Article

Evidence that exposure of the telomere 3′ overhang sequence induces senescence

6 Jan 2003

Abstract excerpt

Normal human cells cease proliferation after a finite number of population doublings, a phenomenon termed replicative senescence. This process, first convincingly described by Hayflick and Moorhead [Hayflick, L. & Moorhead, P. S. (1961) Exp. Cell Res. 25, 595-621] for cultured human fibroblasts 40 years ago, is suggested to be a fundamental defense against cancer. Several events have been demonstrated to induce...

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PMID: 12515865
DOI: 10.1073/pnas.0235444100

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