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Article

Atypical focal MRI lesions in a case of juvenile Alexander's disease.

Annals of neurology - 1 Jan 2003

Probst Eva Neumaier, Hagel Christian, Weisz Vanja, Nagel Sandra, Wittkugel Oliver, Zeumer Hermann, Kohlschütter Alfried

Abstract excerpt

We present a juvenile case of Alexander's disease with atypical focal magnetic resonance imaging-detected lesions and elevated levels of lactate in cerebrospinal fluid. The diagnosis was based on the neuropathological finding of a diffuse accumulation of Rosenthal fibers within the brain and the spinal cord. The diagnosis was confirmed by detection of a mutation in exon 1 at nucleotide position 249 of glial...

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Identifiers

PMID: 12509855
DOI: 10.1002/ana.10382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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