Article
Identification of GFAP gene mutation in hereditary adult-onset Alexander's disease.
Annals of neurology - 1 Dec 2002
Namekawa Michito, Takiyama Yoshihisa, Aoki Yoko, Takayashiki Norio, Sakoe Kumi, Shimazaki Haruo, Taguchi Tomohiro, Tanaka Yasufumi, Nishizawa Masatoyo, Saito Ken, Matsubara Yoichi, Nakano Imaharu
Abstract excerpt
Alexander's disease, a leukodystrophy characterized by Rosenthal fibers (RFs) in the brain, is categorized into three subtypes: infantile, juvenile, and adult. Although most are sporadic, occasional familial Alexander's disease cases have been reported for each subtype. Hereditary adult-onset Alexander's disease shows progressive spastic paresis, bulbar or pseudobulbar palsy, palatal myoclonus...
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